We found inadequate vitamin B status related to the homocysteine pathway in women planning Assisted Reproductive Technology. Moreover, interesting association was found regarding hyperhomocysteinemia in women carrying T allele of the C677T MTHFR polymorphism. A specific supplementation with 5-MTHF and adequate vitamin B12 concentrations before Assisted Reproductive Technology warrant serious consideration, in particular in women carrying T allele of the C677T MTHFR polymorphism.
Homocysteine, vitamin B status and MTHFR polymorphisms in Italian infertile women / Michela Cirillo; Maria Elisabetta Coccia; Monica Attanasio; Cinzia Fatini. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - ELETTRONICO. - 263:(2021), pp. 72-78. [10.1016/j.ejogrb.2021.06.003]
Homocysteine, vitamin B status and MTHFR polymorphisms in Italian infertile women
Michela Cirillo;Maria Elisabetta Coccia;Monica Attanasio;Cinzia Fatini
2021
Abstract
We found inadequate vitamin B status related to the homocysteine pathway in women planning Assisted Reproductive Technology. Moreover, interesting association was found regarding hyperhomocysteinemia in women carrying T allele of the C677T MTHFR polymorphism. A specific supplementation with 5-MTHF and adequate vitamin B12 concentrations before Assisted Reproductive Technology warrant serious consideration, in particular in women carrying T allele of the C677T MTHFR polymorphism.
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Cirillo M, Coccia ME, Attanasio M, Fatini C. Homocysteine, vitamin B status and MTHFR polymorphisms in Italian infertile women. Eur J Obstet Gynecol Reprod Biol..pdf
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