Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged <= 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.

Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) / Bonifazi, M; Mei, F; Skrami, E; Latini, LL; Amico, D; Balestro, E; Bini, F; Bonifazi, F; Caminati, A; Candoli, P; Cinti, S; Contucci, S; Berardino, AD; Harari, S; Levi, G; Lococo, S; Menditto, V; Marchetti, G; Piciucchi, S; Poletti, V; Ravaglia, C; Saetta, M; Svegliati-Baroni, G; Tomassetti, S; Tamburrini, M; Zanforlin, A; Zuccon, U; Zuccatosta, L; Gasparini, S; Carle, F. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - ELETTRONICO. - 10:(2021), pp. 0-0. [10.3390/jcm10061218]

Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)

Bonifazi, M;Candoli, P;Poletti, V;Tomassetti, S;
2021

Abstract

Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged <= 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
2021
10
0
0
Bonifazi, M; Mei, F; Skrami, E; Latini, LL; Amico, D; Balestro, E; Bini, F; Bonifazi, F; Caminati, A; Candoli, P; Cinti, S; Contucci, S; Berardino, AD; Harari, S; Levi, G; Lococo, S; Menditto, V; Marchetti, G; Piciucchi, S; Poletti, V; Ravaglia, C; Saetta, M; Svegliati-Baroni, G; Tomassetti, S; Tamburrini, M; Zanforlin, A; Zuccon, U; Zuccatosta, L; Gasparini, S; Carle, F
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1240720
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