AbstractObjective To evaluate the short term associations between nitrogen dioxide (NO 2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting 398 cities in 22 low to high income countries/regions. Main outcome measures Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. Results On average, a 10 μg/m 3 increase in NO 2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM 10 and PM 2.5, respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO 2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities. Conclusions This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO 2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO 2.

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: Multilocation analysis in 398 cities / Meng X.; Liu C.; Chen R.; Sera F.; Vicedo-Cabrera A.M.; Milojevic A.; Guo Y.; Tong S.; De Sousa Zanotti Stagliorio Coelho M.; Saldiva P.H.N.; Lavigne E.; Correa P.M.; Ortega N.V.; Osorio S.; Garcia; Kysely J.; Urban A.; Orru H.; Maasikmets M.; Jaakkola J.J.K.; Ryti N.; Huber V.; Schneider A.; Katsouyanni K.; Analitis A.; Hashizume M.; Honda Y.; Ng C.F.S.; Nunes B.; Teixeira J.P.; Holobaca I.H.; Fratianni S.; Kim H.; Tobias A.; Iniguez C.; Forsberg B.; Astrom C.; Ragettli M.S.; Guo Y.-L.L.; Pan S.-C.; Li S.; Bell M.L.; Zanobetti A.; Schwartz J.; Wu T.; Gasparrini A.; Kan H.. - In: BMJ. BRITISH MEDICAL JOURNAL. - ISSN 0959-8146. - ELETTRONICO. - 372:(2021), pp. 534.0-534.0. [10.1136/bmj.n534]

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: Multilocation analysis in 398 cities

Sera F.;Zanobetti A.;
2021

Abstract

AbstractObjective To evaluate the short term associations between nitrogen dioxide (NO 2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting 398 cities in 22 low to high income countries/regions. Main outcome measures Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. Results On average, a 10 μg/m 3 increase in NO 2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM 10 and PM 2.5, respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO 2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities. Conclusions This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO 2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO 2.
2021
372
0
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Meng X.; Liu C.; Chen R.; Sera F.; Vicedo-Cabrera A.M.; Milojevic A.; Guo Y.; Tong S.; De Sousa Zanotti Stagliorio Coelho M.; Saldiva P.H.N.; Lavigne E.; Correa P.M.; Ortega N.V.; Osorio S.; Garcia; Kysely J.; Urban A.; Orru H.; Maasikmets M.; Jaakkola J.J.K.; Ryti N.; Huber V.; Schneider A.; Katsouyanni K.; Analitis A.; Hashizume M.; Honda Y.; Ng C.F.S.; Nunes B.; Teixeira J.P.; Holobaca I.H.; Fratianni S.; Kim H.; Tobias A.; Iniguez C.; Forsberg B.; Astrom C.; Ragettli M.S.; Guo Y.-L.L.; Pan S.-C.; Li S.; Bell M.L.; Zanobetti A.; Schwartz J.; Wu T.; Gasparrini A.; Kan H.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1243382
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