Biological agents have had an increased usage during the past years, also in pediatric population. Monoclonal antibodies can cause adverse drug reactions with different pathomechanisms, including type I IgE-mediated hypersensitivity reactions (HR). In this report, we describe 2 children who had a diagnosis of anaphylaxis to rituximab (RTX), confirmed by positive in vivo tests in both cases and elevated tryptase value in one case. We also made a review of the few cases of HR to RTX in pediatric population reported in literature and discuss differential diagnosis and utility of allergy investigations.
Hypersensitivity to Rituximab in Children / Liccioli G.; Simonini G.; Melani F.; Giovannini M.; Ricci S.; Sarti L.; Cavallin M.; Barni S.; Marrani E.; Mori F.. - In: PHARMACOLOGY. - ISSN 0031-7012. - ELETTRONICO. - 106:(2021), pp. 341-344. [10.1159/000511458]
Hypersensitivity to Rituximab in Children
Liccioli G.;Simonini G.;Giovannini M.;Ricci S.;Sarti L.;Barni S.;Marrani E.;Mori F.
2021
Abstract
Biological agents have had an increased usage during the past years, also in pediatric population. Monoclonal antibodies can cause adverse drug reactions with different pathomechanisms, including type I IgE-mediated hypersensitivity reactions (HR). In this report, we describe 2 children who had a diagnosis of anaphylaxis to rituximab (RTX), confirmed by positive in vivo tests in both cases and elevated tryptase value in one case. We also made a review of the few cases of HR to RTX in pediatric population reported in literature and discuss differential diagnosis and utility of allergy investigations.
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