Biological agents have had an increased usage during the past years, also in pediatric population. Monoclonal antibodies can cause adverse drug reactions with different pathomechanisms, including type I IgE-mediated hypersensitivity reactions (HR). In this report, we describe 2 children who had a diagnosis of anaphylaxis to rituximab (RTX), confirmed by positive in vivo tests in both cases and elevated tryptase value in one case. We also made a review of the few cases of HR to RTX in pediatric population reported in literature and discuss differential diagnosis and utility of allergy investigations.
Hypersensitivity to Rituximab in Children / Liccioli G.; Simonini G.; Melani F.; Giovannini M.; Ricci S.; Sarti L.; Cavallin M.; Barni S.; Marrani E.; Mori F.. - In: PHARMACOLOGY. - ISSN 0031-7012. - ELETTRONICO. - 106:(2021), pp. 341-344. [10.1159/000511458]
Hypersensitivity to Rituximab in Children
Liccioli G.;Simonini G.;Giovannini M.;Ricci S.;Marrani E.;
2021
Abstract
Biological agents have had an increased usage during the past years, also in pediatric population. Monoclonal antibodies can cause adverse drug reactions with different pathomechanisms, including type I IgE-mediated hypersensitivity reactions (HR). In this report, we describe 2 children who had a diagnosis of anaphylaxis to rituximab (RTX), confirmed by positive in vivo tests in both cases and elevated tryptase value in one case. We also made a review of the few cases of HR to RTX in pediatric population reported in literature and discuss differential diagnosis and utility of allergy investigations.
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