Overcoming anticancer drug resistance is a major challenge in cancer therapy, requiring innovative strategies that consider the extensive tumor heterogeneity and adaptability. We provide recent evidence highlighting the key role of amino acid (AA) metabolic reprogramming in cancer cells and the supportive microenvironment in driving resistance to anticancer therapies. AAs sustain the acquisition of anticancer resistance by providing essential building blocks for biosynthetic pathways and for maintaining a balanced redox status, and modulating the epigenetic profile of both malignant and non-malignant cells. In addition, AAs support the reduced intrinsic susceptibility of cancer stem cells to antineoplastic therapies. These findings shed new light on the possibility of targeting nonresponding tumors by modulating AA availability through pharmacological or dietary interventions.

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids / Erica Pranzini, Elisa Pardella, Paolo Paoli, Maria Letizia Taddei. - In: TRENDS IN CANCER. - ISSN 2405-8033. - ELETTRONICO. - (2021), pp. 682-699. [10.1016/j.trecan.2021.02.004]

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids

Erica Pranzini;Elisa Pardella;Paolo Paoli;Maria Letizia Taddei
2021

Abstract

Overcoming anticancer drug resistance is a major challenge in cancer therapy, requiring innovative strategies that consider the extensive tumor heterogeneity and adaptability. We provide recent evidence highlighting the key role of amino acid (AA) metabolic reprogramming in cancer cells and the supportive microenvironment in driving resistance to anticancer therapies. AAs sustain the acquisition of anticancer resistance by providing essential building blocks for biosynthetic pathways and for maintaining a balanced redox status, and modulating the epigenetic profile of both malignant and non-malignant cells. In addition, AAs support the reduced intrinsic susceptibility of cancer stem cells to antineoplastic therapies. These findings shed new light on the possibility of targeting nonresponding tumors by modulating AA availability through pharmacological or dietary interventions.
2021
682
699
Goal 3: Good health and well-being for people
Erica Pranzini, Elisa Pardella, Paolo Paoli, Maria Letizia Taddei
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1245223
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