About 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency of actionable genomic alterations. To identify molecular features associated with TTF-1-negative LUAD, we compared the transcriptomic and proteomic profiles of LUAD cell lines. SRGN, a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1-negative LUAD. We therefore investigated the roles and regulation of SRGN in TTF-1-negative LUAD.
SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas / Tanaka, Ichidai; Dayde, Delphine; Tai, Mei Chee; Mori, Haruki; Solis, Luisa M; Tripathi, Satyendra C; Fahrmann, Johannes F; Unver, Nese; Parhy, Gargy; Jain, Rekha; Parra, Edwin R; Murakami, Yoshiko; Aguilar-Bonavides, Clemente; Mino, Barbara; Celiktas, Muge; Dhillon, Dilsher; Casabar, Julian Phillip; Nakatochi, Masahiro; Stingo, Francesco; Baladandayuthapani, Veera; Wang, Hong; Katayama, Hiroyuki; Dennison, Jennifer B; Lorenzi, Philip L; Do, Kim-Anh; Fujimoto, Junya; Behrens, Carmen; Ostrin, Edwin J; Rodriguez-Canales, Jaime; Hase, Tetsunari; Fukui, Takayuki; Kajino, Taisuke; Kato, Seiichi; Yatabe, Yasushi; Hosoda, Waki; Kawaguchi, Koji; Yokoi, Kohei; Chen-Yoshikawa, Toyofumi F; Hasegawa, Yoshinori; Gazdar, Adi F; Wistuba, Ignacio I; Hanash, Samir; Taguchi, Ayumu. - In: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - ISSN 0027-8874. - ELETTRONICO. - 114:(2022), pp. 2.290-2.301. [10.1093/jnci/djab183]
SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas
Stingo, Francesco;
2022
Abstract
About 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency of actionable genomic alterations. To identify molecular features associated with TTF-1-negative LUAD, we compared the transcriptomic and proteomic profiles of LUAD cell lines. SRGN, a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1-negative LUAD. We therefore investigated the roles and regulation of SRGN in TTF-1-negative LUAD.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.