HLA-cw6 gene is associated with more severe and early onset psoriasis. Recent reports have shown that HLA-cw6 status predicts efficacy of some biologic treatments in psoriasis patients. Our study demonstrated that Secukinumab was equally effctive in both cws-Pos and cws-Negative patients with PASI response rates being comparable between the cohorts up to week 72.
Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: results from extension phase of the SUPREME study / Papini M.; Cusano F.; Romanelli M.; Burlando M.; Stinco G.; Girolomoni G.; Peris K.; Potenza C.; Offidani A.; Bartezaghi M.; Aloisi E.; Costanzo A.; Bianchi L.; Bottoni U.; Buligan C.; Brazzelli V.; Campanati A.; Cantoresi F.; Capo A.; Cattaneo A.; Dapavo P.; Giglio M.; Lernia V.; Nuzzo S.; Simone C.; Dusi D.; Fargnoli C.; Flori L.; Franchi C.; Galluzzo M.; Ghilardi A.; Hansel K.; Loconsole F.; Lora V.; Malagoli P.; Malara G.; Mastrandrea V.; Megna M.; Mercuri R.; Musumeci L.; Naldi L.; Narcisi A.; Orsini D.; Pagnanelli G.; Patrizi A.; Pau M.; Pellacani G.; Persechino S.; Piaserico S.; Pietroleonardo L.; Prignano F.; Reseghetti A.; Russo F.; Sirna R.; Skroza N.; Stingeni L.; Trevisini S.; Zane C.; Zichichi L.; Zini A.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - STAMPA. - 181:(2019), pp. 413-414. [10.1111/bjd.18013]
Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: results from extension phase of the SUPREME study
Prignano F.;
2019
Abstract
HLA-cw6 gene is associated with more severe and early onset psoriasis. Recent reports have shown that HLA-cw6 status predicts efficacy of some biologic treatments in psoriasis patients. Our study demonstrated that Secukinumab was equally effctive in both cws-Pos and cws-Negative patients with PASI response rates being comparable between the cohorts up to week 72.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.