This systematic review and meta-analysis were conducted to determine the effects of anthraquinone (AQ) laxatives on colorectal cancer (CRC). We searched PubMed, Embase, Google Scholar, and CENTRAL from inception until March 2021, for randomized controlled trials (RCTs) and observational studies. Through the systematic review, we identified 8 observational studies evaluating AQ laxatives use as a risk factor for CRC development, and 5 studies on CRC risk were included in the metaanalysis using a random-effects model. Through the meta-analysis, we found that a history of AQ laxatives use compared with “other” and “no laxatives” use was associated with CRC development (OR: 1.41; 95% CI: 0.94–2.11), although not at a statistically significant level. The possible association persists even after removal of the outlier studies (OR: 1.51; 95% CI: 0.97–2.34). Selection of cases and controls was judged at low or unclear risk of bias across almost all studies, and the quality of evidence was from moderate to low. In conclusion, it is not possible to associate the use of AQ laxatives with the development of CRC. However, the trend toward an increased risk of CRC provides a strong indication for investigating this issue by performing further high-quality studies.

Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies / Lombardi, Niccolò; Crescioli, Giada; Maggini, Valentina; Bellezza, Raffaele; Landi, Iacopo; Bettiol, Alessandra; Menniti‐Ippolito, Francesca; Ippoliti, Ilaria; Mazzanti, Gabriela; Vitalone, Annabella; Gallo, Eugenia; Sivelli, Francesco; Sofi, Francesco; Gensini, Gian Franco; Vannacci, Alfredo; Firenzuoli, Fabio. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - STAMPA. - 36:(2022), pp. 1093-1101. [10.1002/ptr.7373]

Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies

Lombardi, Niccolò
Writing – Original Draft Preparation
;
Crescioli, Giada
Writing – Original Draft Preparation
;
Maggini, Valentina
Writing – Original Draft Preparation
;
Bettiol, Alessandra
Membro del Collaboration Group
;
Gallo, Eugenia
Investigation
;
Sivelli, Francesco
Formal Analysis
;
Sofi, Francesco
Writing – Review & Editing
;
Gensini, Gian Franco
Writing – Review & Editing
;
Vannacci, Alfredo
Writing – Review & Editing
;
Firenzuoli, Fabio
Writing – Review & Editing
2022

Abstract

This systematic review and meta-analysis were conducted to determine the effects of anthraquinone (AQ) laxatives on colorectal cancer (CRC). We searched PubMed, Embase, Google Scholar, and CENTRAL from inception until March 2021, for randomized controlled trials (RCTs) and observational studies. Through the systematic review, we identified 8 observational studies evaluating AQ laxatives use as a risk factor for CRC development, and 5 studies on CRC risk were included in the metaanalysis using a random-effects model. Through the meta-analysis, we found that a history of AQ laxatives use compared with “other” and “no laxatives” use was associated with CRC development (OR: 1.41; 95% CI: 0.94–2.11), although not at a statistically significant level. The possible association persists even after removal of the outlier studies (OR: 1.51; 95% CI: 0.97–2.34). Selection of cases and controls was judged at low or unclear risk of bias across almost all studies, and the quality of evidence was from moderate to low. In conclusion, it is not possible to associate the use of AQ laxatives with the development of CRC. However, the trend toward an increased risk of CRC provides a strong indication for investigating this issue by performing further high-quality studies.
2022
36
1093
1101
Goal 3: Good health and well-being
Lombardi, Niccolò; Crescioli, Giada; Maggini, Valentina; Bellezza, Raffaele; Landi, Iacopo; Bettiol, Alessandra; Menniti‐Ippolito, Francesca; Ippoliti, Ilaria; Mazzanti, Gabriela; Vitalone, Annabella; Gallo, Eugenia; Sivelli, Francesco; Sofi, Francesco; Gensini, Gian Franco; Vannacci, Alfredo; Firenzuoli, Fabio
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1254019
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