A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.
AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection / Spinicci M.; Mazzoni A.; Borchi B.; Graziani L.; Mazzetti M.; Bartalesi F.; Botta A.; Tilli M.; Pieralli F.; Coppi M.; Giovacchini N.; Colao M.G.; Saccardi R.; Rossolini G.M.; Annunziato F.; Bartoloni A.. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - ELETTRONICO. - (2021), pp. 0-0. [10.1002/eji.202149574]
AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection
Spinicci M.;Mazzoni A.;Graziani L.;Botta A.;Tilli M.;Coppi M.;Giovacchini N.;Saccardi R.;Rossolini G. M.;Annunziato F.;Bartoloni A.
2021
Abstract
A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.
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