A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.
AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection / Spinicci M., Mazzoni A., Borchi B., Graziani L., Mazzetti M., Bartalesi F., Botta A., Tilli M., Pieralli F., Coppi M., Giovacchini N., Colao M.G., Saccardi R., Rossolini G.M., Annunziato F., Bartoloni A.. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - ELETTRONICO. - (2021), pp. 0-0. [10.1002/eji.202149574]
AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection
Spinicci M.;Mazzoni A.;Graziani L.;Botta A.;Tilli M.;Coppi M.;Giovacchini N.;Saccardi R.;Rossolini G. M.;Annunziato F.;Bartoloni A.
2021
Abstract
A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.
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