We present an innovative approach allowing the identification, isolation, and molecular characterization of disease-related exosomes based on their different antigenic reactivities. The designed strategy could be immediately translated into any disease in which exosomes are involved. The identification of specific markers and their subsequent association with exosome subtypes, together with the possibility to engineer target-guided exosome-like particles, could represent the key for the effective adoption of exosomes in clinical practice.

A novel phage display based platform for exosome diversity characterization / Maisano, Domenico; Mimmi, Selena; Dattilo, Vincenzo; Marino, Fabiola; Gentile, Massimo; Vecchio, Eleonora; Fiume, Giuseppe; Nisticò, Nancy; Aloisio, Annamaria; de Santo, Maria Penelope; Desiderio, Giovanni; Musolino, Vincenzo; Nucera, Saverio; Sbrana, Francesca; Andò, Sebastiano; Ferrero, Simone; Morandi, Andrea; Bertoni, Francesco; Quinto, Ileana; Iaccino, Enrico. - In: NANOSCALE. - ISSN 2040-3364. - ELETTRONICO. - (2022), pp. 0-0. [10.1039/d1nr06804k]

A novel phage display based platform for exosome diversity characterization

Sbrana, Francesca;Morandi, Andrea;
2022

Abstract

We present an innovative approach allowing the identification, isolation, and molecular characterization of disease-related exosomes based on their different antigenic reactivities. The designed strategy could be immediately translated into any disease in which exosomes are involved. The identification of specific markers and their subsequent association with exosome subtypes, together with the possibility to engineer target-guided exosome-like particles, could represent the key for the effective adoption of exosomes in clinical practice.
2022
0
0
Maisano, Domenico; Mimmi, Selena; Dattilo, Vincenzo; Marino, Fabiola; Gentile, Massimo; Vecchio, Eleonora; Fiume, Giuseppe; Nisticò, Nancy; Aloisio, Annamaria; de Santo, Maria Penelope; Desiderio, Giovanni; Musolino, Vincenzo; Nucera, Saverio; Sbrana, Francesca; Andò, Sebastiano; Ferrero, Simone; Morandi, Andrea; Bertoni, Francesco; Quinto, Ileana; Iaccino, Enrico
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1256169
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 27
social impact