Cucurbitacins (CUCUs) are triterpenoids known to display potent cytotoxic effects; however, their clinical application is limited due to poor pharmacokinetics and systemic toxicity. This work focuses on the development of c(RGDyK)-CUCU conjugates for the selective delivery of CUCUs to integrin-overexpressing cancer cells.
Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins / Chatzisideri T.,Dalezis P.,Leonidis G., Bousis S., Trafalis D., Bianchini F., Sarli V.. - In: FUTURE MEDICINAL CHEMISTRY. - ISSN 1756-8919. - ELETTRONICO. - 13:(2021), pp. 877-895. [10.4155/fmc-2020-0309]
Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins
Bianchini F.
Writing – Review & Editing
;
2021
Abstract
Cucurbitacins (CUCUs) are triterpenoids known to display potent cytotoxic effects; however, their clinical application is limited due to poor pharmacokinetics and systemic toxicity. This work focuses on the development of c(RGDyK)-CUCU conjugates for the selective delivery of CUCUs to integrin-overexpressing cancer cells.
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