Aims The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems-level analysis. Methods Imaging-based cortical structural maps from a large-scale epilepsy neuroimaging study were overlaid with highly spatially resolved human brain gene expression data from the Allen Human Brain Atlas. Cell-type deconvolution, differential expression analysis and cell-type enrichment analyses were used to identify differences in cell-type distribution. These differences were followed up in post-mortem brain tissue from humans with epilepsy using Iba1 immunolabelling.
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies / Altmann, Andre; Ryten, Mina; Di Nunzio, Martina; Ravizza, Teresa; Tolomeo, Daniele; Reynolds, Regina H.; Somani, Alyma; Bacigaluppi, Marco; Iori, Valentina; Micotti, Edoardo; Di Sapia, Rossella; Cerovic, Milica; Palma, Eleonora; Ruffolo, Gabriele; Botia, Juan A.; Absil, Julie; Alhusaini, Saud; Alvim, Marina K. M.; Auvinen, Pia; Bargallo, Nuria; Bartolini, Emanuele; Bender, Benjamin; Bergo, Felipe P. G.; Bernardes, Tauana; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris C.; Blackmon, Karen; Braga, Barbara; Caligiuri, Maria Eugenia; Calvo, Anna; Carlson, Chad; Carr, Sarah J. A.; Cavalleri, Gianpiero L.; Cendes, Fernando; Chen, Jian; Chen, Shuai; Cherubini, Andrea; Concha, Luis; David, Philippe; Delanty, Norman; Depondt, Chantal; Devinsky, Orrin; Doherty, Colin P.; Domin, Martin; Focke, Niels K.; Foley, Sonya; Franca, Wendy; Gambardella, Antonio; Guerrini, Renzo; Hamandi, Khalid; Hibar, Derrek P.; Isaev, Dmitry; Jackson, Graeme D.; Jahanshad, Neda; Kalviainen, Reetta; Keller, Simon S.; Kochunov, Peter; Kotikalapudi, Raviteja; Kowalczyk, Magdalena A.; Kuzniecky, Ruben; Kwan, Patrick; Labate, Angelo; Langner, Soenke; Lenge, Matteo; Liu, Min; Martin, Pascal; Mascalchi, Mario; Meletti, Stefano; Morita-Sherman, Marcia E.; O'Brien, Terence J.; Pariente, Jose C.; Richardson, Mark P.; Rodriguez-Cruces, Raul; Rummel, Christian; Saavalainen, Taavi; Semmelroch, Mira K.; Severino, Mariasavina; Striano, Pasquale; Thesen, Thomas; Thomas, Rhys H.; Tondelli, Manuela; Tortora, Domenico; Vaudano, Anna Elisabetta; Vivash, Lucy; Podewils, Felix; Wagner, Jan; Weber, Bernd; Wiest, Roland; Yasuda, Clarissa L.; Zhang, Guohao; Zhang, Junsong; Leu, Costin; Avbersek, Andreja; Thom, Maria; Whelan, Christopher D.; Thompson, Paul; McDonald, Carrie R.; Vezzani, Annamaria; Sisodiya, Sanjay M.. - In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. - ISSN 0305-1846. - ELETTRONICO. - 48:(2022), pp. 0-0. [10.1111/nan.12758]
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies
Bartolini, Emanuele;Guerrini, Renzo;Labate, Angelo;Lenge, Matteo;Mascalchi, Mario;
2022
Abstract
Aims The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems-level analysis. Methods Imaging-based cortical structural maps from a large-scale epilepsy neuroimaging study were overlaid with highly spatially resolved human brain gene expression data from the Allen Human Brain Atlas. Cell-type deconvolution, differential expression analysis and cell-type enrichment analyses were used to identify differences in cell-type distribution. These differences were followed up in post-mortem brain tissue from humans with epilepsy using Iba1 immunolabelling.File | Dimensione | Formato | |
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Neuropathology Appl Neurobio - 2021 - Altmann - A systems‐level analysis highlights microglial activation as a modifying.pdf
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