Gambling Disorder (GD) is an impulsive-compulsive disorder characterized by unsuccessful efforts to reduce or stop gambling despite negative outcomes. Deficits in inhibitory control of gambling impulses represents a core symptom dimension of the disorder and the pre-supplementary motor area is thought to be a key node of inhibitory control networks. Although the pathophysiology of GD is not well understood, studies have shown altered brain activity in prefrontal regions (including pre-SMA) of GD patients during response inhibition tasks (Stop Signal Task SST) in addition to functional connectivity abnormalities of SMA during rest. These circuit-level abnormalities represent a potential therapeutic target that could be modulated by brain stimulation therapies such as transcranial magnetic stimulation (TMS). Theta burst stimulation (TBS), is a particularly brief and effective form of TMS that can be inhibitory (cTBS) or excitatory (iTBS).

Abstract #59: Modulating Inhibitory Control Networks in Gambling Disorder with Theta Burst Stimulation / Marras, Anna; Gavazzi, Gioele; Grassi, Giacomo; Rathi, Yogesh; Mascalchi, Mario; Makris, Nikolaos; Camprodon, Joan A.; Pallanti, Stefano. - In: BRAIN STIMULATION. - ISSN 1935-861X. - ELETTRONICO. - 12:(2019), pp. e21-e21. ((Intervento presentato al convegno Brain Stimulation [10.1016/j.brs.2018.12.066].

Abstract #59: Modulating Inhibitory Control Networks in Gambling Disorder with Theta Burst Stimulation

Gavazzi, Gioele;Grassi, Giacomo;Mascalchi, Mario;Pallanti, Stefano
2019

Abstract

Gambling Disorder (GD) is an impulsive-compulsive disorder characterized by unsuccessful efforts to reduce or stop gambling despite negative outcomes. Deficits in inhibitory control of gambling impulses represents a core symptom dimension of the disorder and the pre-supplementary motor area is thought to be a key node of inhibitory control networks. Although the pathophysiology of GD is not well understood, studies have shown altered brain activity in prefrontal regions (including pre-SMA) of GD patients during response inhibition tasks (Stop Signal Task SST) in addition to functional connectivity abnormalities of SMA during rest. These circuit-level abnormalities represent a potential therapeutic target that could be modulated by brain stimulation therapies such as transcranial magnetic stimulation (TMS). Theta burst stimulation (TBS), is a particularly brief and effective form of TMS that can be inhibitory (cTBS) or excitatory (iTBS).
Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation
Brain Stimulation
Marras, Anna; Gavazzi, Gioele; Grassi, Giacomo; Rathi, Yogesh; Mascalchi, Mario; Makris, Nikolaos; Camprodon, Joan A.; Pallanti, Stefano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1256766
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