Thrombocytopenia is common in patients with myelofibrosis and is a well-established adverse prognostic factor. Both of the approved Janus kinase (JAK) inhibitors, ruxolitinib and fedratinib, can worsen thrombocytopenia and have not been evaluated in patients with severe thrombocytopenia.
Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia / Verstovsek, Srdan; Mesa, Ruben; Talpaz, Moshe; Kiladjian, Jean-Jacques; Harrison, Claire N; Oh, Stephen T; Vannucchi, Alessandro M; Rampal, Raajit; Scott, Bart L; Buckley, Sarah A; Craig, Adam R; Roman-Torres, Karisse; Mascarenhas, John O. - In: HAEMATOLOGICA. - ISSN 1592-8721. - ELETTRONICO. - (2021), pp. 1-21. [10.3324/haematol.2021.279415]
Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia
Vannucchi, Alessandro M;
2021
Abstract
Thrombocytopenia is common in patients with myelofibrosis and is a well-established adverse prognostic factor. Both of the approved Janus kinase (JAK) inhibitors, ruxolitinib and fedratinib, can worsen thrombocytopenia and have not been evaluated in patients with severe thrombocytopenia.
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