Type 1 immune response in progressive multiple sclerosis

Frisullo, G.; Plantone, D.; Marti, A.; Iorio, R.; Damato, V.; Nociti, V.; Patanella, A. K.; Bianco, A.; Batocchi, A. P.

doi:10.1016/j.jneuroim.2012.04.019

The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4 +T-bet + and CD8 +T-bet + T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4 +T-bet + or CD8 +T-bet + T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation. © 2012 Elsevier B.V.

Type 1 immune response in progressive multiple sclerosis / Frisullo G.; Plantone D.; Marti A.; Iorio R.; Damato V.; Nociti V.; Patanella A.K.; Bianco A.; Batocchi A.P.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 249:(2012), pp. 112-116. [10.1016/j.jneuroim.2012.04.019]