In their new article in the Journal of Investigative Dermatology, Tseng et al. (2021) confirm that the sensitivity of melanoma cells to anti‒PD-L1 checkpoint inhibitor therapy is correlated with high PD-L1 surface expression. By blocking PD-L1 membrane clearing, controlled by LRP1 and PAI-1, the expression of high-cell-surface levels of PD-L1 was maintained.
A Possible Role for PAI-1 Blockade in Melanoma Immunotherapy / Del Rosso M.; Fibbi G.; Laurenzana A.; Margheri F.; Chilla A.. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - ELETTRONICO. - 141:(2021), pp. 2566-2568. [10.1016/j.jid.2021.05.004]
A Possible Role for PAI-1 Blockade in Melanoma Immunotherapy
Del Rosso M.;Fibbi G.;Laurenzana A.;Margheri F.;Chilla A.
2021
Abstract
In their new article in the Journal of Investigative Dermatology, Tseng et al. (2021) confirm that the sensitivity of melanoma cells to anti‒PD-L1 checkpoint inhibitor therapy is correlated with high PD-L1 surface expression. By blocking PD-L1 membrane clearing, controlled by LRP1 and PAI-1, the expression of high-cell-surface levels of PD-L1 was maintained.
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