MicroRNAs regulatory networks governing the epigenetic landscape of MEN1 gastro-entero-pancreatic neuroendocrine tumor: A case report

By investigating global miRNA expression signatures in matched samples of normal pancreas, pNET, and gastrinoma from a MEN1 clinical case, we highlighted new specific miRNA signatures and confirmed previously selected microRNAs involved in MEN1 gastro‐entero‐pancreatic tumors. These miRNAs have been shown to be organized in two gene regulatory networks with common and distinct functional attributes. While this work clearly represents a starting point, and investigation of a greater number of cases will be required to generalize the results presented, these data make an interesting exploratory contribution to the knowledge of the mechanisms governing MEN1 tumorigenesis.