Human cytoplasmic ferritins are heteropolymers of H and L subunits containing a catalytic ferroxidase center and a nucleation site for iron biomineralization, respectively. Here, ESI-MS successfully detected labile metal-protein interactions revealing the formation of tetra- and octa-iron clusters bound to L subunits, as previously underscored by X-ray crystallography.
Direct detection of iron clusters in L ferritins through ESI-MS experiments / Massai L.; Ciambellotti S.; Cosottini L.; Messori L.; Turano P.; Pratesi A.. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - ELETTRONICO. - 50:(2021), pp. 16464-16467. [10.1039/d1dt03106f]
Direct detection of iron clusters in L ferritins through ESI-MS experiments
Massai L.;Ciambellotti S.;Cosottini L.;Messori L.
;Turano P.
;
2021
Abstract
Human cytoplasmic ferritins are heteropolymers of H and L subunits containing a catalytic ferroxidase center and a nucleation site for iron biomineralization, respectively. Here, ESI-MS successfully detected labile metal-protein interactions revealing the formation of tetra- and octa-iron clusters bound to L subunits, as previously underscored by X-ray crystallography.
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