Human cytoplasmic ferritins are heteropolymers of H and L subunits containing a catalytic ferroxidase center and a nucleation site for iron biomineralization, respectively. Here, ESI-MS successfully detected labile metal-protein interactions revealing the formation of tetra- and octa-iron clusters bound to L subunits, as previously underscored by X-ray crystallography.

Direct detection of iron clusters in L ferritins through ESI-MS experiments / Massai L.; Ciambellotti S.; Cosottini L.; Messori L.; Turano P.; Pratesi A.. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - ELETTRONICO. - 50:(2021), pp. 16464-16467. [10.1039/d1dt03106f]

Direct detection of iron clusters in L ferritins through ESI-MS experiments

Massai L.;Ciambellotti S.;Cosottini L.;Messori L.
;
Turano P.
;
2021

Abstract

Human cytoplasmic ferritins are heteropolymers of H and L subunits containing a catalytic ferroxidase center and a nucleation site for iron biomineralization, respectively. Here, ESI-MS successfully detected labile metal-protein interactions revealing the formation of tetra- and octa-iron clusters bound to L subunits, as previously underscored by X-ray crystallography.
2021
50
16464
16467
Massai L.; Ciambellotti S.; Cosottini L.; Messori L.; Turano P.; Pratesi A.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1259241
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