Glucagon-Like Peptide-2 (GLP-2) is a pleiotropic hormone that plays several roles in different organs and tissues, so being involved in many physiological processes. Among these, it regulates gastrointestinal (GI) tract function binding to a specific G-protein coupled receptor (GLP-2R). Of note, GLP-2R is widely expressed in different cells of the GI tract, including excitatory and inhibitory neurons of the enteric nervous system. In the gut, GLP-2 has been reported to play numerous actions, among which the modulation of motility. Nevertheless, most of the GLP-2 effects and its role in physiological processes are still debated. The aim of this minireview is to summarize the data present in the literature on the control of GI motility by GLP-2, the mechanism through which it occurs, and to discuss the physiological implications of such effects. A better understanding of the role of GLP-2 on GI motor responses may be of importance for the development of new therapeutic approaches in GI dysmotility.

Glucagon-Like Peptide-2 in the Control of Gastrointestinal Motility: Physiological Implications / Maria Caterina Baccari, Maria Giuliana Vannucchi , Eglantina Idrizaj. - In: CURRENT PROTEIN & PEPTIDE SCIENCE. - ISSN 1389-2037. - ELETTRONICO. - 23:(2022), pp. 61-69. [10.2174/1389203723666220217142935]

Glucagon-Like Peptide-2 in the Control of Gastrointestinal Motility: Physiological Implications

Maria Caterina Baccari;Maria Giuliana Vannucchi;Eglantina Idrizaj
2022

Abstract

Glucagon-Like Peptide-2 (GLP-2) is a pleiotropic hormone that plays several roles in different organs and tissues, so being involved in many physiological processes. Among these, it regulates gastrointestinal (GI) tract function binding to a specific G-protein coupled receptor (GLP-2R). Of note, GLP-2R is widely expressed in different cells of the GI tract, including excitatory and inhibitory neurons of the enteric nervous system. In the gut, GLP-2 has been reported to play numerous actions, among which the modulation of motility. Nevertheless, most of the GLP-2 effects and its role in physiological processes are still debated. The aim of this minireview is to summarize the data present in the literature on the control of GI motility by GLP-2, the mechanism through which it occurs, and to discuss the physiological implications of such effects. A better understanding of the role of GLP-2 on GI motor responses may be of importance for the development of new therapeutic approaches in GI dysmotility.
2022
23
61
69
Maria Caterina Baccari, Maria Giuliana Vannucchi , Eglantina Idrizaj
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1262049
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