Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CKD) over time. A variety of insults can trigger AKI; however, chemotherapy-associated nephrotoxicity is increasingly recognized as a significant side effect of chemotherapy. New biomarkers are urgently needed to identify patients at high risk of developing chemotherapy-associated nephrotoxicity and subsequent AKI. However, a lack of understanding of cellular mechanisms that trigger chemotherapy-related nephrotoxicity has hindered the identification of effective biomarkers to date. In this review, we aim to (1) describe the known and potential mechanisms related to chemotherapy-induced AKI; (2) summarize the available biomarkers for early AKI detection, and (3) raise awareness of chemotherapy-induced AKI.

Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI / Letizia De Chiara, Gianmarco Lugli, Gianluca Villa, Valentina Raglianti, Faeq Husain-Syed, Fiammetta Ravaglia, Paola Romagnani, Elena Lazzeri. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - (2022), pp. 2638-2660.

Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI

Letizia De Chiara
;
Gianluca Villa;Valentina Raglianti;Paola Romagnani;Elena Lazzeri
2022

Abstract

Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CKD) over time. A variety of insults can trigger AKI; however, chemotherapy-associated nephrotoxicity is increasingly recognized as a significant side effect of chemotherapy. New biomarkers are urgently needed to identify patients at high risk of developing chemotherapy-associated nephrotoxicity and subsequent AKI. However, a lack of understanding of cellular mechanisms that trigger chemotherapy-related nephrotoxicity has hindered the identification of effective biomarkers to date. In this review, we aim to (1) describe the known and potential mechanisms related to chemotherapy-induced AKI; (2) summarize the available biomarkers for early AKI detection, and (3) raise awareness of chemotherapy-induced AKI.
2022
2638
2660
Letizia De Chiara, Gianmarco Lugli, Gianluca Villa, Valentina Raglianti, Faeq Husain-Syed, Fiammetta Ravaglia, Paola Romagnani, Elena Lazzeri
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1262428
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