Jagged ends of plasma DNA are a recently recognized class of fragmentomic markers for cell-free DNA, reflecting the activity of nucleases. A number of recent studies have also highlighted the importance of jagged ends in the context of pregnancy and oncology. However, knowledge regarding the generation of jagged ends is incomplete.
Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus / Ding, Spencer C; Chan, Rebecca W Y; Peng, Wenlei; Huang, Liangbo; Zhou, Ze; Hu, Xi; Volpi, Stefano; Hiraki, Linda T; Vaglio, Augusto; Fenaroli, Paride; Bocca, Paola; Tam, Lai Shan; Wong, Priscilla C H; Tam, Lydia H P; Jiang, Peiyong; Chiu, Rossa W K; Allen Chan, K C; Dennis Lo, Y M. - In: CLINICAL CHEMISTRY. - ISSN 1530-8561. - ELETTRONICO. - 68:(2022), pp. 917-926. [10.1093/clinchem/hvac050]
Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus
Vaglio, Augusto;
2022
Abstract
Jagged ends of plasma DNA are a recently recognized class of fragmentomic markers for cell-free DNA, reflecting the activity of nucleases. A number of recent studies have also highlighted the importance of jagged ends in the context of pregnancy and oncology. However, knowledge regarding the generation of jagged ends is incomplete.
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