Ovarian cancer is the fifth leading cause of cancer-related deaths in women. Standard treatment consists of tumor debulking surgery followed by platinum and paclitaxel chemotherapy; yet, despite the initial response, about 70-75% of patients develop resistance to chemotherapy. Gold compounds represent a family of very promising anticancer drugs. Among them, we previously investigated the cytotoxic and pro-apoptotic properties of Au(NHC) and Au(NHC)2PF6, i.e., a monocarbene gold(I) complex and the corresponding bis(carbene) complex. Gold compounds are known to alter the redox state of cells interacting with free cysteine and selenocysteine residues of several proteins. Herein, a redox proteomic study has been carried out to elucidate the mechanisms of cytotoxicity in A2780 human ovarian cancer cells.

The effects of two gold-N-heterocyclic carbene (NHC) complexes in ovarian cancer cells: a redox proteomic study / Massai, Lara; Messori, Luigi; Carpentieri, Andrea; Amoresano, Angela; Melchiorre, Chiara; Fiaschi, Tania; Modesti, Alessandra; Gamberi, Tania; Magherini, Francesca. - In: CANCER CHEMOTHERAPY AND PHARMACOLOGY. - ISSN 0344-5704. - ELETTRONICO. - 89:(2022), pp. 809-823. [10.1007/s00280-022-04438-y]

The effects of two gold-N-heterocyclic carbene (NHC) complexes in ovarian cancer cells: a redox proteomic study

Massai, Lara;Messori, Luigi;Fiaschi, Tania;Modesti, Alessandra;Gamberi, Tania;Magherini, Francesca
2022

Abstract

Ovarian cancer is the fifth leading cause of cancer-related deaths in women. Standard treatment consists of tumor debulking surgery followed by platinum and paclitaxel chemotherapy; yet, despite the initial response, about 70-75% of patients develop resistance to chemotherapy. Gold compounds represent a family of very promising anticancer drugs. Among them, we previously investigated the cytotoxic and pro-apoptotic properties of Au(NHC) and Au(NHC)2PF6, i.e., a monocarbene gold(I) complex and the corresponding bis(carbene) complex. Gold compounds are known to alter the redox state of cells interacting with free cysteine and selenocysteine residues of several proteins. Herein, a redox proteomic study has been carried out to elucidate the mechanisms of cytotoxicity in A2780 human ovarian cancer cells.
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Massai, Lara; Messori, Luigi; Carpentieri, Andrea; Amoresano, Angela; Melchiorre, Chiara; Fiaschi, Tania; Modesti, Alessandra; Gamberi, Tania; Magherini, Francesca
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1279941
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