The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell-derived neural stem cells (NSCs) and neurons. Centrosome-associated proteins were largely cell type-specific, with protein hubs involved in RNA dynamics.

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity / Adam C O'Neill # , Fatma Uzbas # , Giulia Antognolli # , Florencia Merino # , Kalina Draganova , Alex Jäck , Sirui Zhang , Giorgia Pedini , Julia P Schessner , Kimberly Cramer , Aloys Schepers , Fabian Metzger , Miriam Esgleas , Pawel Smialowski , Renzo Guerrini , Sven Falk , Regina Feederle , Saskia Freytag , Zefeng Wang , Melanie Bahlo , Ralf Jungmann , Claudia Bagni , Georg H H Borner , Stephen P Robertson , Stefanie M Hauck , Magdalena Götz. - In: SCIENCE. - ISSN 0036-8075. - ELETTRONICO. - (2022), pp. 1286-1288. [10.1126/science.abf9088]

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity

Renzo Guerrini;
2022

Abstract

The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell-derived neural stem cells (NSCs) and neurons. Centrosome-associated proteins were largely cell type-specific, with protein hubs involved in RNA dynamics.
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Adam C O'Neill # , Fatma Uzbas # , Giulia Antognolli # , Florencia Merino # , Kalina Draganova , Alex Jäck , Sirui Zhang , Giorgia Pedini , Julia P Schessner , Kimberly Cramer , Aloys Schepers , Fabian Metzger , Miriam Esgleas , Pawel Smialowski , Renzo Guerrini , Sven Falk , Regina Feederle , Saskia Freytag , Zefeng Wang , Melanie Bahlo , Ralf Jungmann , Claudia Bagni , Georg H H Borner , Stephen P Robertson , Stefanie M Hauck , Magdalena Götz
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/1280420
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