The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell-derived neural stem cells (NSCs) and neurons. Centrosome-associated proteins were largely cell type-specific, with protein hubs involved in RNA dynamics.
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity / Adam C O'Neill #, F.U.#.. - In: SCIENCE. - ISSN 0036-8075. - ELETTRONICO. - (2022), pp. 1286-1288. [10.1126/science.abf9088]
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity
Renzo Guerrini;
2022
Abstract
The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell-derived neural stem cells (NSCs) and neurons. Centrosome-associated proteins were largely cell type-specific, with protein hubs involved in RNA dynamics.
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