Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data

Seymour, M Lopez; Leon, M Aksman; Neil, P Oxtoby; Sjoerd, B Vos; Rao, Jun; Kaestner, Erik; Alhusaini, Saud; Alvim, Marina; Bender, Benjamin; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Bonilha, Leonardo; Caciagli, Lorenzo; Caldairou, Benoit; Maria Eugenia Caligiuri,; Calvet, Angels; Cendes, Fernando; Concha, Luis; Conde-Blanco, Estefania; Davoodi-Bojd, Esmaeil; Christophe De Bézenac,; Delanty, Norman; Patricia, M Desmond; Devinsky, Orrin; Domin, Martin; John, S Duncan; Niels, K Focke; Foley, Sonya; Fortunato, Francesco; Galovic, Marian; Gambardella, Antonio; Gleichgerrcht, Ezequiel; Guerrini, Renzo; Hamandi, Khalid; Ives-Deliperi, Victoria; Graeme, D Jackson; Jahanshad, Neda; Simon, S Keller; Kochunov, Peter; Kotikalapudi, Raviteja; Barbara A, K Kreilkamp; Labate, Angelo; Larivière, Sara; Lenge, Matteo; Lui, Elaine; Malpas, Charles; Martin, Pascal; Mascalchi, Mario; Sarah, E Medland; Meletti, Stefano; Marcia, E Morita-Sherman; Thomas, W Owen; Richardson, Mark; Riva, Antonella; Rüber, Theodor; Sinclair, Ben; Soltanian-Zadeh, Hamid; Dan, J Stein; Striano, Pasquale; Peter, N Taylor; Sophia, I Thomopoulos 37; Paul, M Thompson; Tondelli, Manuela; Anna Elisabetta Vaudano,; Vivash, Lucy; Wang, Yujiang; Weber, Bernd; Christopher, D Whelan; Wiest, Roland; Gavin, P Winston; Clarissa Lin Yasuda,; Carrie, R Mcdonald; C Alexander 3, Daniel; Sanjay, M Sisodiya; Altmann, Andre; ENIGMA-Epilepsy Working Group,

doi:10.1111/epi.17316

Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features.

Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data / Seymour M Lopez, Leon M Aksman , Neil P Oxtoby , Sjoerd B Vos , Jun Rao , Erik Kaestner , Saud Alhusaini , Marina Alvim , Benjamin Bender , Andrea Bernasconi , Neda Bernasconi , Boris Bernhardt , Leonardo Bonilha , Lorenzo Caciagli , Benoit Caldairou , Maria Eugenia Caligiuri , Angels Calvet , Fernando Cendes , Luis Concha , Estefania Conde-Blanco , Esmaeil Davoodi-Bojd , Christophe de Bézenac , Norman Delanty , Patricia M Desmond , Orrin Devinsky , Martin Domin, John S Duncan , Niels K Focke, Sonya Foley , Francesco Fortunato , Marian Galovic , Antonio Gambardella , Ezequiel Gleichgerrcht , Renzo Guerrini , Khalid Hamandi , Victoria Ives-Deliperi , Graeme D Jackson , Neda Jahanshad , Simon S Keller , Peter Kochunov , Raviteja Kotikalapudi , Barbara A K Kreilkamp , Angelo Labate , Sara Larivière , Matteo Lenge , Elaine Lui , Charles Malpas , Pascal Martin , Mario Mascalchi , Sarah E Medland , Stefano Meletti , Marcia E Morita-Sherman , Thomas W Owen , Mark Richardson , Antonella Riva, Theodor Rüber , Ben Sinclair, Hamid Soltanian-Zadeh , Dan J Stein , Pasquale Striano , Peter N Taylor , Sophia I Thomopoulos 37, Paul M Thompson , Manuela Tondelli , Anna Elisabetta Vaudano , Lucy Vivash , Yujiang Wang , Bernd Weber , Christopher D Whelan , Roland Wiest , Gavin P Winston , Clarissa Lin Yasuda , Carrie R McDonald , Daniel C Alexander 3, Sanjay M Sisodiya , Andre Altmann , ENIGMA-Epilepsy Working Group. - In: EPILEPSIA. - ISSN 0013-9580. - ELETTRONICO. - 63:(2022), pp. 2081-2095. [10.1111/epi.17316]