Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls.

Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy / Bo-Yong Park , Sara Larivière , Raul Rodríguez-Cruces , Jessica Royer , Shahin Tavakol , Yezhou Wang , Lorenzo Caciagli , Maria Eugenia Caligiuri , Antonio Gambardella , Luis Concha , Simon S Keller , Fernando Cendes , Marina K M Alvim , Clarissa Yasuda , Leonardo Bonilha , Ezequiel Gleichgerrcht , Niels K Focke , Barbara A K Kreilkamp , Martin Domin , Felix von Podewils , Soenke Langner , Christian Rummel , Michael Rebsamen , Roland Wiest , Pascal Martin , Raviteja Kotikalapudi , Benjamin Bender , Terence J O'Brien , Meng Law , Benjamin Sinclair , Lucy Vivash , Patrick Kwan , Patricia M Desmond , Charles B Malpas , Elaine Lui, Saud Alhusaini , Colin P Doherty , Gianpiero L Cavalleri , Norman Delanty , Reetta Kälviäinen , Graeme D Jackson , Magdalena Kowalczyk , Mario Mascalchi , Mira Semmelroch , Rhys H Thomas , Hamid Soltanian-Zadeh , Esmaeil Davoodi-Bojd , Junsong Zhang , Matteo Lenge , Renzo Guerrini , Emanuele Bartolini , Khalid Hamandi , Sonya Foley , Bernd Weber , Chantal Depondt , Julie Absil , Sarah J A Carr , Eugenio Abela , Mark P Richardson , Orrin Devinsky , Mariasavina Severino , Pasquale Striano , Costanza Parodi , Domenico Tortora , Sean N Hatton, Sjoerd B Vos , John S Duncan , Marian Galovic , Christopher D Whelan , Núria Bargalló , Jose Pariente , Estefania Conde-Blanco , Anna Elisabetta Vaudan Manuela Tondelli , Stefano Meletti , Xiang-Zhen Kong , Clyde Francks , Simon E Fisher , Benoit Caldairou , Mina Ryten , Angelo Labate , Sanjay M Sisodiya , Paul M Thompson , Carrie R McDonald , Andrea Bernasconi , Neda Bernasconi , Boris C Bernhardt. - In: BRAIN. - ISSN 0006-8950. - ELETTRONICO. - 145:(2022), pp. 1285-1298. [10.1093/brain/awab417]

Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy

Renzo Guerrini;
2022

Abstract

Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls.
145
1285
1298
Bo-Yong Park , Sara Larivière , Raul Rodríguez-Cruces , Jessica Royer , Shahin Tavakol , Yezhou Wang , Lorenzo Caciagli , Maria Eugenia Caligiuri , Antonio Gambardella , Luis Concha , Simon S Keller , Fernando Cendes , Marina K M Alvim , Clarissa Yasuda , Leonardo Bonilha , Ezequiel Gleichgerrcht , Niels K Focke , Barbara A K Kreilkamp , Martin Domin , Felix von Podewils , Soenke Langner , Christian Rummel , Michael Rebsamen , Roland Wiest , Pascal Martin , Raviteja Kotikalapudi , Benjamin Bender , Terence J O'Brien , Meng Law , Benjamin Sinclair , Lucy Vivash , Patrick Kwan , Patricia M Desmond , Charles B Malpas , Elaine Lui, Saud Alhusaini , Colin P Doherty , Gianpiero L Cavalleri , Norman Delanty , Reetta Kälviäinen , Graeme D Jackson , Magdalena Kowalczyk , Mario Mascalchi , Mira Semmelroch , Rhys H Thomas , Hamid Soltanian-Zadeh , Esmaeil Davoodi-Bojd , Junsong Zhang , Matteo Lenge , Renzo Guerrini , Emanuele Bartolini , Khalid Hamandi , Sonya Foley , Bernd Weber , Chantal Depondt , Julie Absil , Sarah J A Carr , Eugenio Abela , Mark P Richardson , Orrin Devinsky , Mariasavina Severino , Pasquale Striano , Costanza Parodi , Domenico Tortora , Sean N Hatton, Sjoerd B Vos , John S Duncan , Marian Galovic , Christopher D Whelan , Núria Bargalló , Jose Pariente , Estefania Conde-Blanco , Anna Elisabetta Vaudan Manuela Tondelli , Stefano Meletti , Xiang-Zhen Kong , Clyde Francks , Simon E Fisher , Benoit Caldairou , Mina Ryten , Angelo Labate , Sanjay M Sisodiya , Paul M Thompson , Carrie R McDonald , Andrea Bernasconi , Neda Bernasconi , Boris C Bernhardt
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/1280479
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