Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies

Costa, Anna-Maria; Tommaso Lo Barco,; Spezia, Elisabetta; Conti, Valerio; Roli, Laura; Marini, Lorenza; Minghetti, Sara; Caramaschi, Elisa; Pietrangelo, Laura; Pecoraro, Luca; D'Achille, Fabio; Accorsi, Paola; Trenti, Tommaso; Melani, Federico; Marini, Carla; Guerrini, Renzo; Darra, Francesca; Bergonzini, Patrizia; Biagini, Giuseppe

doi:10.3390/jpm12040527

Children with epilepsy and identified as responders to antiseizure medications (ASMs) were found to present markedly higher ghrelin plasma levels when compared to drug-resistant patients. However, it was undetermined if this phenotype could be influenced by the ASMs. Here, we prospectively investigated total ghrelin and des-acyl ghrelin (DAG) plasma levels by enzyme-linked immunosorbent assay before and after ASM administration. Inclusion criteria were: (i) subject with a suspicion of epilepsy; (ii) age ranging from 0 to 16 years; and (iii) informed consent signed by parents or caregivers.

Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies / Anna-Maria Costa , Tommaso Lo Barco, Elisabetta Spezia , Valerio Conti , Laura Roli , Lorenza Marini , Sara Minghetti , Elisa Caramaschi , Laura Pietrangelo , Luca Pecoraro , Fabio D'Achille, Paola Accorsi , Tommaso Trenti , Federico Melani , Carla Marini , Renzo Guerrini , Francesca Darra , Patrizia Bergonzini , Giuseppe Biagini. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - ELETTRONICO. - 12:(2022), pp. 0-0. [10.3390/jpm12040527]