Children with epilepsy and identified as responders to antiseizure medications (ASMs) were found to present markedly higher ghrelin plasma levels when compared to drug-resistant patients. However, it was undetermined if this phenotype could be influenced by the ASMs. Here, we prospectively investigated total ghrelin and des-acyl ghrelin (DAG) plasma levels by enzyme-linked immunosorbent assay before and after ASM administration. Inclusion criteria were: (i) subject with a suspicion of epilepsy; (ii) age ranging from 0 to 16 years; and (iii) informed consent signed by parents or caregivers.

Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies / Anna-Maria Costa , Tommaso Lo Barco, Elisabetta Spezia , Valerio Conti , Laura Roli , Lorenza Marini , Sara Minghetti , Elisa Caramaschi , Laura Pietrangelo , Luca Pecoraro , Fabio D'Achille, Paola Accorsi , Tommaso Trenti , Federico Melani , Carla Marini , Renzo Guerrini , Francesca Darra , Patrizia Bergonzini , Giuseppe Biagini. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - ELETTRONICO. - 12:(2022), pp. 0-0. [10.3390/jpm12040527]

Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies

Lorenza Marini;Renzo Guerrini;
2022

Abstract

Children with epilepsy and identified as responders to antiseizure medications (ASMs) were found to present markedly higher ghrelin plasma levels when compared to drug-resistant patients. However, it was undetermined if this phenotype could be influenced by the ASMs. Here, we prospectively investigated total ghrelin and des-acyl ghrelin (DAG) plasma levels by enzyme-linked immunosorbent assay before and after ASM administration. Inclusion criteria were: (i) subject with a suspicion of epilepsy; (ii) age ranging from 0 to 16 years; and (iii) informed consent signed by parents or caregivers.
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Anna-Maria Costa , Tommaso Lo Barco, Elisabetta Spezia , Valerio Conti , Laura Roli , Lorenza Marini , Sara Minghetti , Elisa Caramaschi , Laura Pietrangelo , Luca Pecoraro , Fabio D'Achille, Paola Accorsi , Tommaso Trenti , Federico Melani , Carla Marini , Renzo Guerrini , Francesca Darra , Patrizia Bergonzini , Giuseppe Biagini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1280971
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