IMPORTANCE New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. OBJECTIVE To evaluate the efficacy and safety of fenfluramine in patients with LGS.
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial / Kelly G Knupp , Ingrid E Scheffer , Berten Ceulemans , Joseph E Sullivan , Katherine C Nickels , Lieven Lagae , Renzo Guerrini , Sameer M Zuberi , Rima Nabbout, Kate Riney , Svetlana Shore , Anupam Agarwal , Michael Lock , Gail M Farfel , Bradley S Galer , Arnold R Gammaitoni , Ronald Davis , Antonio Gil-Nagel. - In: JAMA NEUROLOGY. - ISSN 2168-6149. - ELETTRONICO. - 79:(2022), pp. 554-564. [10.1001/jamaneurol.2022.0829]
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial
Renzo Guerrini;
2022
Abstract
IMPORTANCE New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. OBJECTIVE To evaluate the efficacy and safety of fenfluramine in patients with LGS.
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