The interest in Cannabis sativa L. phytocomplex as a medicinal tool is a recently-emerging topic. Neurodegenerative diseases represent a promising field of application for cannabis and its preparations, as most of this pathologic conditions relies on an inflammatory etiology. Several cannabis constituents display anti-inflammatory effects targeting multiple pathways. In this review, a comprehensive overview of the available literature on C. sativa constituents activities in neuroinflammation is given. On the basis that the anti-inflammatory activity of cannabis is not attributable to only a single constituent, we discuss the possible advantages of administering the whole phytocomplex in order to fully exploit the “entourage effect” in neuroinflammatory-related conditions

Cannabis sativa L. Constituents and Their Role in Neuroinflammation / Vittoria Borgonetti; Paolo Governa; Monica Montopoli; Marco Biagi. - In: CURRENT BIOACTIVE COMPOUNDS. - ISSN 1875-6646. - STAMPA. - 15:(2019), pp. 147-158. [10.2174/1573407214666180703130525]

Cannabis sativa L. Constituents and Their Role in Neuroinflammation

Vittoria Borgonetti;
2019

Abstract

The interest in Cannabis sativa L. phytocomplex as a medicinal tool is a recently-emerging topic. Neurodegenerative diseases represent a promising field of application for cannabis and its preparations, as most of this pathologic conditions relies on an inflammatory etiology. Several cannabis constituents display anti-inflammatory effects targeting multiple pathways. In this review, a comprehensive overview of the available literature on C. sativa constituents activities in neuroinflammation is given. On the basis that the anti-inflammatory activity of cannabis is not attributable to only a single constituent, we discuss the possible advantages of administering the whole phytocomplex in order to fully exploit the “entourage effect” in neuroinflammatory-related conditions
15
147
158
Vittoria Borgonetti; Paolo Governa; Monica Montopoli; Marco Biagi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1281431
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