Magic nitrile! A highly chemoselective iridium-catalyzed reductive Strecker reaction of tertiary amides and lactams has been developed. The protocol is simple to perform, broad in scope, highly efficient, and has been successfully applied to the late-stage functionalization of tertiary amides in drugs, naturally occurring alkaloids and peptides. TMDS=tetramethyldisiloxane, TMS=trimethylsilyl, Vaska's complex=IrCl(CO)[P(C6H5)3]2.
Iridium-catalyzed reductive strecker reaction for late-stage amide and lactam cyanation / Ángel L. Fuentes de Arriba, Elena Lenci, Mahendra Sonawane, Odilon Formery, Darren J. Dixon. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - ELETTRONICO. - (2017), pp. 3655-3659. [10.1002/anie.201612367]
Iridium-catalyzed reductive strecker reaction for late-stage amide and lactam cyanation
Elena Lenci;
2017
Abstract
Magic nitrile! A highly chemoselective iridium-catalyzed reductive Strecker reaction of tertiary amides and lactams has been developed. The protocol is simple to perform, broad in scope, highly efficient, and has been successfully applied to the late-stage functionalization of tertiary amides in drugs, naturally occurring alkaloids and peptides. TMDS=tetramethyldisiloxane, TMS=trimethylsilyl, Vaska's complex=IrCl(CO)[P(C6H5)3]2.
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
