Blue LED light photobiomodulation of inflammatory response and new tissue formation in mice skin wounds

The manuscript represents an attempt to understand the effects of blue light 6 days post-treatment on acute wounds in a murine model. In particular, after ascertaining the impact of this procedure on wound healing and considering the parameters relating to re-epithelialization, the cellular infiltrate, and extracellular matrix responses are considered. The irradiation with blue LED light induces an increase in the mast cell degranulation index, followed by an enhancement in the response of the cellular infiltrate. This event was coupled with the fibroblasts' differentiation into myofibroblasts (verified through the intermediate forms and specific markers), which leads to simultaneous activation of the extracellular matrix and neocollagenesis. Therefore, the authors conclude that blue light irradiation can evoke photobiomodulation of the wound and represents a valuable treatment for accelerating healing.