Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up.

Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review / Mannelli G.; Comini L.V.; Sacchetto A.; Santoro R.; Spinelli G.; Bonomo P.; Desideri I.; Bossi P.; Orlandi E.; Alderotti G.; Franchi A.; Palomba A.; Eccher A.; Marchioni D.; Nocini R.; Piazza C.; Molteni G.. - In: HEAD & NECK. - ISSN 1043-3074. - ELETTRONICO. - 44:(2022), pp. 1961-1975. [10.1002/hed.27062]

Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review

Mannelli G.;Comini L. V.;Santoro R.;Spinelli G.;Bonomo P.;Desideri I.;Alderotti G.;Palomba A.;
2022

Abstract

Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up.
44
1961
1975
Mannelli G.; Comini L.V.; Sacchetto A.; Santoro R.; Spinelli G.; Bonomo P.; Desideri I.; Bossi P.; Orlandi E.; Alderotti G.; Franchi A.; Palomba A.; Eccher A.; Marchioni D.; Nocini R.; Piazza C.; Molteni G.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1282666
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact