Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 2

Fiorentino, A.; Laudicella, R.; Ciurlia, E.; Annunziata, S.; Lancellotta, V.; Mapelli, P.; Tuscano, C.; Caobelli, F.; Evangelista, L.; Marino, L.; Quartuccio, N.; Fiore, M.; Borghetti, P.; Chiaravalloti, A.; Ricci, M.; Desideri, I.; Alongi, P.

doi:10.1016/j.critrevonc.2019.03.008

Aim: Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer. Methods: A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume. Results: FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer. Conclusion: Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.

Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 2 / Fiorentino A.; Laudicella R.; Ciurlia E.; Annunziata S.; Lancellotta V.; Mapelli P.; Tuscano C.; Caobelli F.; Evangelista L.; Marino L.; Quartuccio N.; Fiore M.; Borghetti P.; Chiaravalloti A.; Ricci M.; Desideri I.; Alongi P.. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - ELETTRONICO. - 139:(2019), pp. 117-124. [10.1016/j.critrevonc.2019.03.008]