Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 2

Fiorentino, A.; Laudicella, R.; Ciurlia, E.; Annunziata, S.; Lancellotta, V.; Mapelli, P.; Tuscano, C.; Caobelli, F.; Evangelista, L.; Marino, L.; Quartuccio, N.; Fiore, M.; Borghetti, P.; Chiaravalloti, A.; Ricci, M.; Desideri, I.; Alongi, P.

doi:10.1016/j.critrevonc.2019.03.008

Aim: Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer. Methods: A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume. Results: FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer. Conclusion: Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.

Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 2 / Fiorentino A., Laudicella R., Ciurlia E., Annunziata S., Lancellotta V., Mapelli P., Tuscano C., Caobelli F., Evangelista L., Marino L., Quartuccio N., Fiore M., Borghetti P., Chiaravalloti A., Ricci M., Desideri I., Alongi P.. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - ELETTRONICO. - 139:(2019), pp. 117-124. [10.1016/j.critrevonc.2019.03.008]