Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusing on the main Gram-negative bacterial species (Pseudomonas aeruginosa, Burkholderia cenocepacia, Achromobacter xylosoxidans, Stenotrophomonas maltophilia) for which a predominant role of RND pumps has been associated to MDR phenotypes.

Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens / Scoffone, Viola Camilla; Trespidi, Gabriele; Barbieri, Giulia; Irudal, Samuele; Perrin, Elena; Buroni, Silvia. - In: ANTIBIOTICS. - ISSN 2079-6382. - ELETTRONICO. - 10:(2021), pp. 863-887. [10.3390/antibiotics10070863]

Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens

Perrin, Elena
;
2021

Abstract

Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusing on the main Gram-negative bacterial species (Pseudomonas aeruginosa, Burkholderia cenocepacia, Achromobacter xylosoxidans, Stenotrophomonas maltophilia) for which a predominant role of RND pumps has been associated to MDR phenotypes.
2021
10
863
887
Scoffone, Viola Camilla; Trespidi, Gabriele; Barbieri, Giulia; Irudal, Samuele; Perrin, Elena; Buroni, Silvia
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1284422
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