Arginine in older patients with persistent atrial fibrillation: A link to endothelial dysfunction?

In conclusion, this pilot analysis seems to support the hypothesis that AF is independently associated with endothelial dysfunction, as expressed by reduced arginine plasma levels. This condition worsening atrial cardiomyopathy and left atrium remodeling could augment the incidence of thromboembolic complications. Importantly, age, synergistically interacting with AF, could further increase the risk profile of patients. Specific studies with an adequate sample size should address these issues to prevent arrhythmia-related morbidity, disability and mortality.