A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group introduced the new International Consensus Classification (ICC) for Myeloid Neoplasms and Acute Leukemias. This current in-depth review focuses on the ICC-2022 category of JAK2 mutation-prevalent myeloproliferative neoplasms (MPNs): essential thrombocythemia, polycythemia vera, primary myelofibrosis, and MPN, unclassifiable. The ICC MPN subcommittee chose to preserve the primary role of bone marrow morphology in disease classification and diagnostics, while also acknowledging the complementary role of genetic markers for establishing clonality, facilitating MPN subtype designation, and disease prognostication.

The international consensus classification of myeloid neoplasms and acute Leukemias: myeloproliferative neoplasms / Thiele, Jürgen; Kvasnicka, Hans Michael; Orazi, Attilio; Gianelli, Umberto; Gangat, Naseema; Vannucchi, Alessandro M; Barbui, Tiziano; Arber, Daniel A; Tefferi, Ayalew. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - ELETTRONICO. - (2022), pp. 1200-1228. [10.1002/ajh.26751]

The international consensus classification of myeloid neoplasms and acute Leukemias: myeloproliferative neoplasms

Vannucchi, Alessandro M
Writing – Original Draft Preparation
;
2022

Abstract

A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group introduced the new International Consensus Classification (ICC) for Myeloid Neoplasms and Acute Leukemias. This current in-depth review focuses on the ICC-2022 category of JAK2 mutation-prevalent myeloproliferative neoplasms (MPNs): essential thrombocythemia, polycythemia vera, primary myelofibrosis, and MPN, unclassifiable. The ICC MPN subcommittee chose to preserve the primary role of bone marrow morphology in disease classification and diagnostics, while also acknowledging the complementary role of genetic markers for establishing clonality, facilitating MPN subtype designation, and disease prognostication.
1200
1228
Thiele, Jürgen; Kvasnicka, Hans Michael; Orazi, Attilio; Gianelli, Umberto; Gangat, Naseema; Vannucchi, Alessandro M; Barbui, Tiziano; Arber, Daniel A; Tefferi, Ayalew
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1286375
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