In patients affected by myelofibrosis with hepatic myeloid metaplasia (HMM), portal hypertension (PHT) complications may develop. In this case series, we analysed the efficacy and safety of transjugular portosystemic shunt (TIPS) in the treatment of PHT-related complications and its effects on the nutritional status. Six patients were evaluated and the average follow-up period after TIPS was 33 (IQR 5) months. None of the patients developed hepatic failure, nor any recurrence of variceal bleeding was recorded. No additional paracentesis or endoscopic prophylactic treatment for PHT-related complications were required. In all subjects, the average dose of diuretics was almost halved three months after TIPS. Three patients died during the follow-up, but none for liver-related causes. All patients showed an improvement in the global nutritional status. In conclusion, TIPS represent an effective and safe treatment option for patients affected by complications of PHT secondary to HMM and drives to an improvement of the nutritional status.

Portosystemic shunt is an effective treatment for complications of portal hypertension in hepatic myeloid metaplasia and improves nutritional status / Aspite, Silvia; Schepis, Filippo; Roccarina, Davide; Gitto, Stefano; Citone, Michele; Di Bonaventura, Chiara; Bianchini, Marcello; Arena, Umberto; Vannucchi, Alessandro M; Guglielmelli, Paola; Campani, Francesca; Fanelli, Fabrizio; Marra, Fabio; Vizzutti, Francesco. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - ELETTRONICO. - 42:(2022), pp. 419-424. [10.1111/liv.15148]

Portosystemic shunt is an effective treatment for complications of portal hypertension in hepatic myeloid metaplasia and improves nutritional status

Aspite, Silvia;Roccarina, Davide;Gitto, Stefano;Di Bonaventura, Chiara;Arena, Umberto;Vannucchi, Alessandro M
Writing – Review & Editing
;
Guglielmelli, Paola
Writing – Review & Editing
;
Campani, Francesca;Fanelli, Fabrizio;Marra, Fabio;Vizzutti, Francesco
2022

Abstract

In patients affected by myelofibrosis with hepatic myeloid metaplasia (HMM), portal hypertension (PHT) complications may develop. In this case series, we analysed the efficacy and safety of transjugular portosystemic shunt (TIPS) in the treatment of PHT-related complications and its effects on the nutritional status. Six patients were evaluated and the average follow-up period after TIPS was 33 (IQR 5) months. None of the patients developed hepatic failure, nor any recurrence of variceal bleeding was recorded. No additional paracentesis or endoscopic prophylactic treatment for PHT-related complications were required. In all subjects, the average dose of diuretics was almost halved three months after TIPS. Three patients died during the follow-up, but none for liver-related causes. All patients showed an improvement in the global nutritional status. In conclusion, TIPS represent an effective and safe treatment option for patients affected by complications of PHT secondary to HMM and drives to an improvement of the nutritional status.
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419
424
Aspite, Silvia; Schepis, Filippo; Roccarina, Davide; Gitto, Stefano; Citone, Michele; Di Bonaventura, Chiara; Bianchini, Marcello; Arena, Umberto; Vannucchi, Alessandro M; Guglielmelli, Paola; Campani, Francesca; Fanelli, Fabrizio; Marra, Fabio; Vizzutti, Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1286396
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