Sealing t-tubules increases the energy cost of cardiac contraction

The work “Disruption of transverse-tubular network reduces energy efficiency in cardiac muscle contraction” by Mellor et al1 that appears in this issue of Acta Physiologica brings together the scientific interests and technical skills of two worlds: that of fine intact cardiac muscle energetics and mechanics (eg Tran et al2 and other studies by Loiselle and his collaborators) and the one of disease-associated cardiac t-tubule remodelling (eg Crossman et al3 and other studies by Soeller and his collaborators).