A relationship between the urinary albumin excretion rate (UAE) and different types of tumors has been previously described but little is known about UAE and renal cell cancer (RCC). We evaluated the prognostic significance of UAE and its correlation with tumor clinicopathological findings in patients with RCC treated with recombinant interleukin-2 (rIL-2) and recombinant interferon-alpha (rIFN-alpha). Because rIL-2 and rIFN-alpha increase glomerular permeability, we also determined whether the first immunotherapy cycle induced a significant increase in UAE and whether it was related to tumor parameters.
Prognostic significance of albuminuria in patients with renal cell cancer / Vaglio, Augusto; Buzio, Luca; Cravedi, Paolo; Pavone, Laura; Garini, Giovanni; Buzio, Carlo. - In: THE JOURNAL OF UROLOGY. - ISSN 0022-5347. - ELETTRONICO. - 170:(2003), pp. ---. [10.1097/01.ju.0000085984.90991.9a]
Prognostic significance of albuminuria in patients with renal cell cancer
Vaglio, Augusto;
2003
Abstract
A relationship between the urinary albumin excretion rate (UAE) and different types of tumors has been previously described but little is known about UAE and renal cell cancer (RCC). We evaluated the prognostic significance of UAE and its correlation with tumor clinicopathological findings in patients with RCC treated with recombinant interleukin-2 (rIL-2) and recombinant interferon-alpha (rIFN-alpha). Because rIL-2 and rIFN-alpha increase glomerular permeability, we also determined whether the first immunotherapy cycle induced a significant increase in UAE and whether it was related to tumor parameters.
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