HER-2 (ErbB-2, c-erbB2 or Her2/neu), a member of the HER-family, is directly involved in the pathogenesis and progression of several human cancers; as such, it is also often considered as a poor prognostic factor. Following the revolutionary impact of anti-HER-2 therapy in breast cancer patients, the role of HER-2 and its blockade has also been extensively evaluated in other tumor types, including gastric and colorectal adenocarcinoma. The aims of this review are to recall the important results achieved with the use of HER-2 inhibitors in both gastric and colorectal cancer, and to discuss on the updates available on the role of HER-2 as prognostic and predictive factor in these malignancies.

HER-2 inhibition in gastric and colorectal cancers: tangible achievements, novel acquisitions and future perspectives / Fanotto, Valentina; Ongaro, Elena; Rihawi, Karim; Avallone, Antonio; Silvestris, Nicola; Fornaro, Lorenzo; Vasile, Enrico; Antonuzzo, Lorenzo; Leone, Francesco; Rosati, Gerardo; Giuliani, Francesco; Bordonaro, Roberto; Scartozzi, Mario; De Maglio, Giovanna; Negri, Francesca V; Fasola, Gianpiero; Aprile, Giuseppe. - In: ONCOTARGET. - ISSN 1949-2553. - STAMPA. - 7:(2016), pp. 69060-69074. [10.18632/oncotarget.11264]

HER-2 inhibition in gastric and colorectal cancers: tangible achievements, novel acquisitions and future perspectives

Vasile, Enrico;Antonuzzo, Lorenzo;
2016

Abstract

HER-2 (ErbB-2, c-erbB2 or Her2/neu), a member of the HER-family, is directly involved in the pathogenesis and progression of several human cancers; as such, it is also often considered as a poor prognostic factor. Following the revolutionary impact of anti-HER-2 therapy in breast cancer patients, the role of HER-2 and its blockade has also been extensively evaluated in other tumor types, including gastric and colorectal adenocarcinoma. The aims of this review are to recall the important results achieved with the use of HER-2 inhibitors in both gastric and colorectal cancer, and to discuss on the updates available on the role of HER-2 as prognostic and predictive factor in these malignancies.
7
69060
69074
Fanotto, Valentina; Ongaro, Elena; Rihawi, Karim; Avallone, Antonio; Silvestris, Nicola; Fornaro, Lorenzo; Vasile, Enrico; Antonuzzo, Lorenzo; Leone, Francesco; Rosati, Gerardo; Giuliani, Francesco; Bordonaro, Roberto; Scartozzi, Mario; De Maglio, Giovanna; Negri, Francesca V; Fasola, Gianpiero; Aprile, Giuseppe
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1287165
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 20
social impact