A 42-year-old man with a cardiac tamponade underwent an urgent pericardiotomy that showed tumoral tissue, covering the surface of the right atrium. The tumor was then partially excised, and the histological examination revealed the presence of a moderately-differentiated angiosarcoma. The patient was then referred to the oncology unit and scheduled for a chemotherapy schedule including Epirubicin (60 mg/m(2), on days 1 and 2) plus Ifosfamide (2000 mg/m(2), on days 1 to 3) and Uromitexan (2000 mg/m(2) at hours 0, 4, 8 after IFO). All drugs were administered every three weeks. After two cycles, a restaging work-up revealed a partial remission. The treatment was continued for another two cycles. A new evaluation by cardiac MRI evidenced a local and distant (lung) progression of disease. The patient died after three months. This paper confirms that cardiac angiosarcoma is a fatal disease, and the prognosis is usually 6-11 months from time of diagnosis.

Primary cardiac angiosarcoma: a fatal disease / Antonuzzo, L; Rotella, V; Mazzoni, F; Doni, L; Bianchini, D; Garbini, F; Maio, V; Di Costanzo, F. - In: CASE REPORTS IN MEDICINE. - ISSN 1687-9627. - STAMPA. - 2009:(2009), pp. 591512.1-591512.4. [10.1155/2009/591512]

Primary cardiac angiosarcoma: a fatal disease

Antonuzzo, L;
2009

Abstract

A 42-year-old man with a cardiac tamponade underwent an urgent pericardiotomy that showed tumoral tissue, covering the surface of the right atrium. The tumor was then partially excised, and the histological examination revealed the presence of a moderately-differentiated angiosarcoma. The patient was then referred to the oncology unit and scheduled for a chemotherapy schedule including Epirubicin (60 mg/m(2), on days 1 and 2) plus Ifosfamide (2000 mg/m(2), on days 1 to 3) and Uromitexan (2000 mg/m(2) at hours 0, 4, 8 after IFO). All drugs were administered every three weeks. After two cycles, a restaging work-up revealed a partial remission. The treatment was continued for another two cycles. A new evaluation by cardiac MRI evidenced a local and distant (lung) progression of disease. The patient died after three months. This paper confirms that cardiac angiosarcoma is a fatal disease, and the prognosis is usually 6-11 months from time of diagnosis.
2009
1
4
Antonuzzo, L; Rotella, V; Mazzoni, F; Doni, L; Bianchini, D; Garbini, F; Maio, V; Di Costanzo, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1287167
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