In the recent X-ACT (Xeloda in Adjuvant Colon cancer Therapy) trial, oral capecitabine (Xeloda) demonstrated superior efficacy and an improved safety profile compared with infused fluorouracil + leucovorin (folinic acid) [FU+LV] in patients with Dukes' C colorectal cancer. We used the X-ACT results to determine the cost effectiveness of capecitabine compared with FU+LV from the perspective of the Italian National Health Service (NHS).
Capecitabine versus bolus fluorouracil plus leucovorin (folinic acid) as adjuvant chemotherapy for patients with Dukes' C colon cancer : economic evaluation in an Italian NHS setting / Di Costanzo, Francesco; Ravasio, Roberto; Sobrero, Alberto; Bertetto, Oscar; Vinante, Orazio; Luppi, Gabriele; Labianca, Roberto; Amadori, Dino; Barone, Carlo; Carlo Merlano, Marco; Longo, Flavia; Mansueto, Giovanni; Antonuzzo, Lorenzo; Gasperoni, Silvia. - In: CLINICAL DRUG INVESTIGATION. - ISSN 1173-2563. - STAMPA. - 28:(2008), pp. 645-655. [10.2165/00044011-200828100-00005]
Capecitabine versus bolus fluorouracil plus leucovorin (folinic acid) as adjuvant chemotherapy for patients with Dukes' C colon cancer : economic evaluation in an Italian NHS setting
Antonuzzo, Lorenzo;Gasperoni, Silvia
2008
Abstract
In the recent X-ACT (Xeloda in Adjuvant Colon cancer Therapy) trial, oral capecitabine (Xeloda) demonstrated superior efficacy and an improved safety profile compared with infused fluorouracil + leucovorin (folinic acid) [FU+LV] in patients with Dukes' C colorectal cancer. We used the X-ACT results to determine the cost effectiveness of capecitabine compared with FU+LV from the perspective of the Italian National Health Service (NHS).
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