Cardiomyopathies are a heterogeneous collection of diseases that have in common primary functional and structural abnormalities of the heart muscle, often genetically determined. The most effective categorization of cardiomyopathies is based on the presenting phenotype, with hypertrophic, dilated, arrhythmogenic, and restrictive cardiomyopathy as the prototypes. Sex modulates the prevalence, morpho-functional manifestations and clinical course of cardiomyopathies. Aspects as diverse as ion channel expression and left ventricular remodeling differ in male and female patients with myocardial disease, although the reasons for this are poorly understood. Moreover, clinical differences may also result from complex societal/environmental discrepancies between sexes that may disadvantage women. This review provides a state-of-the-art appraisal of the influence of sex on cardiomyopathies, highlighting the many gaps in knowledge and open research questions.

Sex-Related Differences in Genetic Cardiomyopathies / Argirò, Alessia; Ho, Carolyn; Day, Sharlene M; van der Velden, Jolanda; Cerbai, Elisabetta; Saberi, Sara; Tardiff, Jil C; Lakdawala, Neal K; Olivotto, Iacopo. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - ELETTRONICO. - 11:(2022), pp. 0-0. [10.1161/JAHA.121.024947]

Sex-Related Differences in Genetic Cardiomyopathies

van der Velden, Jolanda;Cerbai, Elisabetta;Olivotto, Iacopo
2022

Abstract

Cardiomyopathies are a heterogeneous collection of diseases that have in common primary functional and structural abnormalities of the heart muscle, often genetically determined. The most effective categorization of cardiomyopathies is based on the presenting phenotype, with hypertrophic, dilated, arrhythmogenic, and restrictive cardiomyopathy as the prototypes. Sex modulates the prevalence, morpho-functional manifestations and clinical course of cardiomyopathies. Aspects as diverse as ion channel expression and left ventricular remodeling differ in male and female patients with myocardial disease, although the reasons for this are poorly understood. Moreover, clinical differences may also result from complex societal/environmental discrepancies between sexes that may disadvantage women. This review provides a state-of-the-art appraisal of the influence of sex on cardiomyopathies, highlighting the many gaps in knowledge and open research questions.
2022
11
0
0
Argirò, Alessia; Ho, Carolyn; Day, Sharlene M; van der Velden, Jolanda; Cerbai, Elisabetta; Saberi, Sara; Tardiff, Jil C; Lakdawala, Neal K; Olivotto, Iacopo
File in questo prodotto:
File Dimensione Formato  
JAHA.121.024947.pdf

accesso aperto

Tipologia: Pdf editoriale (Version of record)
Licenza: Creative commons
Dimensione 846.33 kB
Formato Adobe PDF
846.33 kB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1291314
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 16
social impact