Mavacamten, a cardiac myosin inhibitor, improved peak VO2 in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in the EXPLORER-HCM study. The mechanism for mavacamten-related improvements in exercise physiology was further assessed by cardiopulmonary exercise testing (CPET). Mavacamten improved a range of CPET parameters beyond peak VO2, including peak-independent parameters, indicating consistent and broad benefits on maximal exercise capacity as well as on submaximal exertional tolerance.
THE EFFECT OF MAVACAMTEN ON CARDIOPULMONARY EXERCISE TESTING PERFORMANCE OF PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN EXPLORER-HCM / Wheeler, Matthew Thomas; Olivotto, Iacopo; Elliott, Perry M.; Saberi, Sara; Owens, Anjali Tiku; Maurer, Mathew S.; Masri, Ahmad; Sehnert, Amy; Edelberg, Jay; Li, Wanying; Florea, Victoria; Malhotra, Rajeev; Wang, Andrew; Oreziak, Artur; Jacoby, Daniel; Myers, Jonathan N.. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - ELETTRONICO. - 79:(2022), pp. 237-237. [10.1016/S0735-1097(22)01228-1]
THE EFFECT OF MAVACAMTEN ON CARDIOPULMONARY EXERCISE TESTING PERFORMANCE OF PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN EXPLORER-HCM
Olivotto, Iacopo;
2022
Abstract
Mavacamten, a cardiac myosin inhibitor, improved peak VO2 in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in the EXPLORER-HCM study. The mechanism for mavacamten-related improvements in exercise physiology was further assessed by cardiopulmonary exercise testing (CPET). Mavacamten improved a range of CPET parameters beyond peak VO2, including peak-independent parameters, indicating consistent and broad benefits on maximal exercise capacity as well as on submaximal exertional tolerance.
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