Aims: To describe the proportion of patients with syncope among those affected by hypertrophic cardiomyopathy (HCM) and the relevance of syncope as risk factor for sudden cardiac death and life-threatening arrhythmic events.Method and results: Systematic review of original articles that assessed syncope in HCM patients. Literature search of PubMed including all English publications from 1973 to 2021.We found 57 articles for a total of 21.791 patients; of these, 14 studies reported on arrhythmic events in the follow-up. Syncope was reported in 15.8% (3.452 of 21.791) patients. It was considered unexplained in 91% of cases. Life-threatening arrhythmic events occurred in 3.6% of non-syncopal patients and in 7.7% of syncopal patients during a mean follow-up of 5.6 years. A relative risk of 1.99 (95%CI 1.39 to 2.86) was estimated for syncope patients by the random effect model using Haldane continuity correction for 0 events.Conclusions: In the current practice, the cause of syncope remained unexplained in most patients affected by HCM. The management of patients seems mainly driven by risk stratification rather than identification of the aetiology of syncope. There is a need of precise instructions how to apply the recommendations of current guidelines to this disease, which tests are indicated and how to interpret their findings.The protocol was registered in Prospero (ID: 275963).

Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis / Mascia, Giuseppe; Crotti, Lia; Groppelli, Antonella; Canepa, Marco; Merlo, Andrea Carlo; Benenati, Stefano; Di Donna, Paolo; Della Bona, Roberta; Soranna, Davide; Zambon, Antonella; Porto, Italo; Olivotto, Iacopo; Parati, Gianfranco; Brignole, Michele; Cecchi, Franco. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - STAMPA. - 357:(2022), pp. 88-94. [10.1016/j.ijcard.2022.03.028]

Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis

Mascia, Giuseppe;Olivotto, Iacopo;Cecchi, Franco
2022

Abstract

Aims: To describe the proportion of patients with syncope among those affected by hypertrophic cardiomyopathy (HCM) and the relevance of syncope as risk factor for sudden cardiac death and life-threatening arrhythmic events.Method and results: Systematic review of original articles that assessed syncope in HCM patients. Literature search of PubMed including all English publications from 1973 to 2021.We found 57 articles for a total of 21.791 patients; of these, 14 studies reported on arrhythmic events in the follow-up. Syncope was reported in 15.8% (3.452 of 21.791) patients. It was considered unexplained in 91% of cases. Life-threatening arrhythmic events occurred in 3.6% of non-syncopal patients and in 7.7% of syncopal patients during a mean follow-up of 5.6 years. A relative risk of 1.99 (95%CI 1.39 to 2.86) was estimated for syncope patients by the random effect model using Haldane continuity correction for 0 events.Conclusions: In the current practice, the cause of syncope remained unexplained in most patients affected by HCM. The management of patients seems mainly driven by risk stratification rather than identification of the aetiology of syncope. There is a need of precise instructions how to apply the recommendations of current guidelines to this disease, which tests are indicated and how to interpret their findings.The protocol was registered in Prospero (ID: 275963).
357
88
94
Mascia, Giuseppe; Crotti, Lia; Groppelli, Antonella; Canepa, Marco; Merlo, Andrea Carlo; Benenati, Stefano; Di Donna, Paolo; Della Bona, Roberta; Soranna, Davide; Zambon, Antonella; Porto, Italo; Olivotto, Iacopo; Parati, Gianfranco; Brignole, Michele; Cecchi, Franco
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0167527322003850-main.pdf

embargo fino al 21/11/2023

Tipologia: Pdf editoriale (Version of record)
Licenza: Creative commons
Dimensione 1.21 MB
Formato Adobe PDF
1.21 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1291326
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 3
social impact