This paper presents a mathematical model capable to reproduce a celebrated phenomenon in blood microcirculation known as Fåhræus effect, since its discovery by Robin Fåhræus (1929). This consists in a decaying of the relative hematocrit in small vessels as the vessel diameter decreases. The key point of the model is a formula, direct consequence of the basic principles of fluid dynamics, that links the relative hematocrit to the reservoir hematocrit and the vessel diameter, which confirms the observed behaviour. To test the model we selected, among the few experiments carried on since then, those performed by Barbee and Cokelet (1971). The agreement is remarkable. An extended comparison is also carried out with a celebrated empirical formula proposed by Pries et al. (1992) to describe the same phenomenon.

A theoretical model for the Fåhræus effect in medium-large microvessels / Farina, Angiolo; Fasano, Antonio; Rosso, Fabio. - In: JOURNAL OF THEORETICAL BIOLOGY. - ISSN 0022-5193. - ELETTRONICO. - 558:(2022), pp. 7.0-7.0. [10.1016/j.jtbi.2022.111355]

A theoretical model for the Fåhræus effect in medium-large microvessels

Farina, Angiolo
;
Fasano, Antonio;Rosso, Fabio
2022

Abstract

This paper presents a mathematical model capable to reproduce a celebrated phenomenon in blood microcirculation known as Fåhræus effect, since its discovery by Robin Fåhræus (1929). This consists in a decaying of the relative hematocrit in small vessels as the vessel diameter decreases. The key point of the model is a formula, direct consequence of the basic principles of fluid dynamics, that links the relative hematocrit to the reservoir hematocrit and the vessel diameter, which confirms the observed behaviour. To test the model we selected, among the few experiments carried on since then, those performed by Barbee and Cokelet (1971). The agreement is remarkable. An extended comparison is also carried out with a celebrated empirical formula proposed by Pries et al. (1992) to describe the same phenomenon.
2022
558
0
0
Farina, Angiolo; Fasano, Antonio; Rosso, Fabio
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1291425
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