Hypogonadism is frequent with a prevalence of 2% in the general population. Hypogonadism may derive from any con dition able to disrupt the hypothalamic-pituitary-testis (HPT) axis at one or more levels. Hypogonadism may be classified according to the age of onset, its potential reversibility and level of the HPT axis damage. The latter categorization is useful to decide on the treatment. Damages to the hypothalamus pituitary may benefit from either GnRH, gonadotropin or T therapy with the former carrying the advantage of stimulating spermatogenesis. Conversely, when the testis is damaged, T therapy is the only option and restoration of spermatogenesis is not possible. Therefore, the choice of therapy is primarily based on the diagnosis and patients’ needs and both should be carefully considered.

Pharmacotherapy of male hypogonadism / Giulia Rastrelli, Linda Vignozzi, Giovanni Corona, Mario Maggi. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - ELETTRONICO. - 68:(In corso di stampa), pp. 1-7.

Pharmacotherapy of male hypogonadism

Giulia Rastrelli;Linda Vignozzi;Giovanni Corona;Mario Maggi
In corso di stampa

Abstract

Hypogonadism is frequent with a prevalence of 2% in the general population. Hypogonadism may derive from any con dition able to disrupt the hypothalamic-pituitary-testis (HPT) axis at one or more levels. Hypogonadism may be classified according to the age of onset, its potential reversibility and level of the HPT axis damage. The latter categorization is useful to decide on the treatment. Damages to the hypothalamus pituitary may benefit from either GnRH, gonadotropin or T therapy with the former carrying the advantage of stimulating spermatogenesis. Conversely, when the testis is damaged, T therapy is the only option and restoration of spermatogenesis is not possible. Therefore, the choice of therapy is primarily based on the diagnosis and patients’ needs and both should be carefully considered.
In corso di stampa
68
1
7
Giulia Rastrelli, Linda Vignozzi, Giovanni Corona, Mario Maggi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1293718
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