Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) currently represent the standard of care for the initial treatment of patients with metastatic hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. The aim of our study is to evaluate the safety of the use of concomitant radiation therapy (RT) in a consecutive series of HR+/HER2- patients treated in two academic institutions with CDK4/6i in the metastatic setting.
Safety of CDK4/6 inhibitors and concomitant radiation therapy in patients affected by metastatic breast cancer / Visani, L., Livi, L., Ratosa, I., Orazem, M., Ribnikar, D., Saieva, C., Becherini, C., Salvestrini, V., Scoccimarro, E., Valzano, M., Cerbai, C., Desideri, I., Bernini, M., Orzalesi, L., Nori, J., Bianchi, S., Morandi, A., Meattini, I.. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - ELETTRONICO. - 177:(2022), pp. 40-45. [10.1016/j.radonc.2022.10.023]
Safety of CDK4/6 inhibitors and concomitant radiation therapy in patients affected by metastatic breast cancer
Visani, Luca;Livi, Lorenzo;Becherini, Carlotta;Salvestrini, Viola;Scoccimarro, Erika;Valzano, Marianna;Cerbai, Cecilia;Desideri, Isacco;Bernini, Marco;Orzalesi, Lorenzo;Bianchi, Simonetta;Morandi, Andrea;Meattini, Icro
2022
Abstract
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) currently represent the standard of care for the initial treatment of patients with metastatic hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. The aim of our study is to evaluate the safety of the use of concomitant radiation therapy (RT) in a consecutive series of HR+/HER2- patients treated in two academic institutions with CDK4/6i in the metastatic setting.
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