Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) currently represent the standard of care for the initial treatment of patients with metastatic hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. The aim of our study is to evaluate the safety of the use of concomitant radiation therapy (RT) in a consecutive series of HR+/HER2- patients treated in two academic institutions with CDK4/6i in the metastatic setting.
Safety of CDK4/6 inhibitors and concomitant radiation therapy in patients affected by metastatic breast cancer / Visani, Luca; Livi, Lorenzo; Ratosa, Ivica; Orazem, Miha; Ribnikar, Domen; Saieva, Calogero; Becherini, Carlotta; Salvestrini, Viola; Scoccimarro, Erika; Valzano, Marianna; Cerbai, Cecilia; Desideri, Isacco; Bernini, Marco; Orzalesi, Lorenzo; Nori, Jacopo; Bianchi, Simonetta; Morandi, Andrea; Meattini, Icro. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - ELETTRONICO. - 177:(2022), pp. 40-45. [10.1016/j.radonc.2022.10.023]
Safety of CDK4/6 inhibitors and concomitant radiation therapy in patients affected by metastatic breast cancer
Visani, Luca;Livi, Lorenzo;Becherini, Carlotta;Salvestrini, Viola;Scoccimarro, Erika;Valzano, Marianna;Cerbai, Cecilia;Desideri, Isacco;Bernini, Marco;Orzalesi, Lorenzo;Bianchi, Simonetta;Morandi, Andrea;Meattini, Icro
2022
Abstract
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) currently represent the standard of care for the initial treatment of patients with metastatic hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. The aim of our study is to evaluate the safety of the use of concomitant radiation therapy (RT) in a consecutive series of HR+/HER2- patients treated in two academic institutions with CDK4/6i in the metastatic setting.
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