: Although immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, nephrotoxicity is less common but often underestimated due to difficult diagnosis. Management usually consists of treatment discontinuation and/or corticosteroid use. In this review, we summarize current knowledge of ICI-induced nephrotoxicity, evaluating drawbacks and future perspectives.

Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge / Catalano, Martina; Roviello, Giandomenico; Galli, Ilaria Camilla; Santi, Raffaella; Nesi, Gabriella. - In: FRONTIERS IN MEDICINE. - ISSN 2296-858X. - STAMPA. - 9:(2022), pp. 1014257-1014267. [10.3389/fmed.2022.1014257]

Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge

Catalano, Martina;Roviello, Giandomenico
;
Galli, Ilaria Camilla;Santi, Raffaella;Nesi, Gabriella
2022

Abstract

: Although immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, nephrotoxicity is less common but often underestimated due to difficult diagnosis. Management usually consists of treatment discontinuation and/or corticosteroid use. In this review, we summarize current knowledge of ICI-induced nephrotoxicity, evaluating drawbacks and future perspectives.
2022
9
1014257
1014267
Catalano, Martina; Roviello, Giandomenico; Galli, Ilaria Camilla; Santi, Raffaella; Nesi, Gabriella
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1295546
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