Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes-Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.
MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy / Rodriquenz, Maria Grazia; Roviello, Giandomenico; D'Angelo, Alberto; Lavacchi, Daniele; Roviello, Franco; Polom, Karol. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - STAMPA. - 9:(2020), pp. 1427-1439. [10.3390/jcm9051427]
MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy
Roviello, Giandomenico;Lavacchi, Daniele;
2020
Abstract
Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes-Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.
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