Leishmaniasis is a cause of infection associated with hemophagocytic lymphohistiocytosis (HLH). The measurement of the CD8(+) CD38(high)/HLA-DR+ T cells in children presenting with acute onset of shock and multisystem organ failure represents an important parameter to distinguish HLH from sepsis or healthy control. Conclusion: We report a case series of 4 Italian children suffering from HLH secondary to visceral Leishmaniasis in which the lymphocyte subset assay suggests a potential role of CD38(high)/HLA-DR+ CD8(+) T cells as HLH diagnostic biomarkers.

CD38high/HLA-DR+ CD8+ T cells as potential biomarker of hemophagocytic lymphohistiocytosis secondary to visceral Leishmania infection / Mastrolia, Maria Vincenza; Boscia, Silvia; Galli, Luisa; Lodi, Lorenzo; Pisano, Laura; Maccora, Ilaria; Ricci, Silvia; Pagnini, Ilaria; Marrani, Edoardo; Azzari, Chiara; Simonini, Gabriele. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - ELETTRONICO. - (2023), pp. 0-0. [10.1007/s00431-022-04789-x]

CD38high/HLA-DR+ CD8+ T cells as potential biomarker of hemophagocytic lymphohistiocytosis secondary to visceral Leishmania infection

Boscia, Silvia;Galli, Luisa;Lodi, Lorenzo;Pisano, Laura;Maccora, Ilaria;Ricci, Silvia;Pagnini, Ilaria;Marrani, Edoardo;Azzari, Chiara;Simonini, Gabriele
2023

Abstract

Leishmaniasis is a cause of infection associated with hemophagocytic lymphohistiocytosis (HLH). The measurement of the CD8(+) CD38(high)/HLA-DR+ T cells in children presenting with acute onset of shock and multisystem organ failure represents an important parameter to distinguish HLH from sepsis or healthy control. Conclusion: We report a case series of 4 Italian children suffering from HLH secondary to visceral Leishmaniasis in which the lymphocyte subset assay suggests a potential role of CD38(high)/HLA-DR+ CD8(+) T cells as HLH diagnostic biomarkers.
2023
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Mastrolia, Maria Vincenza; Boscia, Silvia; Galli, Luisa; Lodi, Lorenzo; Pisano, Laura; Maccora, Ilaria; Ricci, Silvia; Pagnini, Ilaria; Marrani, Edoar...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1300517
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